000009613 001__ 9613
000009613 005__ 20240125143602.0
000009613 0247_ $$2DOI$$a10.6083/m900nv17v
000009613 037__ $$aIR
000009613 245__ $$aDietary magnesium manipulation to elucidate distal nephron physiology in a mouse model
000009613 260__ $$bOregon Health and Science University
000009613 269__ $$a2022
000009613 336__ $$aCapstone
000009613 502__ $$gMedicine (Undergraduate Medical Education)
000009613 502__ $$bM.D.
000009613 520__ $$aThis study investigates whether in a magnesium-deficient state, the administration of an amiloride bolus can cause an increase in magnesium absorption in the distal convoluted tubule when compared to a magnesium-replete state. Additionally, the impact if magnesium on NCC activity was investigated. The amiloride response experiment helped support the conclusion that a low magnesium state causes increased urinary potassium excretion, likely through a combination of NCC inhibition and ROMK disinhibition. The magnesium reversal experiment supports the conclusion that no permanent tubular damage occurs to the distal nephron affecting NCC expression. Further studies are necessary to better understand the complex relationships between magnesium, potassium, and sodium management by NCC, ROMK, and ENaC in the distal nephron.
000009613 540__ $$fCC BY
000009613 650__ $$aSodium$$026139
000009613 650__ $$aAmiloride$$014552
000009613 650__ $$aMagnesium$$021742
000009613 650__ $$aPotassium$$024467
000009613 6531_ $$ancc
000009613 6531_ $$anephron
000009613 691__ $$aSchool of Medicine$$041369
000009613 7001_ $$aKummer, Alissa$$uOregon Health and Science University$$041354
000009613 7201_ $$aMcCormick, James$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000009613 7201_ $$aMaeoka, Yujiro$$uOregon Health and Science University$$041354$$7Personal$$eCo-PI
000009613 8564_ $$9edeb7bfb-5643-4d64-92cb-81adec9ae01a$$s266174$$uhttps://digitalcollections.ohsu.edu/record/9613/files/Kummer.Alissa.CaptionWeek.2022.pdf
000009613 905__ $$a/rest/prod/m9/00/nv/17/m900nv17v
000009613 909CO $$ooai:digitalcollections.ohsu.edu:9613$$pstudent-work
000009613 980__ $$aScholarly Project Capstones