@article{IR, recid = {9619}, author = {Pommert, Kathleen and Alexander, Timothy and Haese, Nicole}, title = {Characterizing a novel, broad spectrum antiviral small molecule}, publisher = {Oregon Health and Science University}, school = {M.D.}, address = {2022}, number = {IR}, abstract = {This is a basic science project to study the mechanism of a novel, broad-spectrum antiviral small molecule series. The small molecule series, SR-33001, inhibits Herpes, Alpha, and Flavi viruses in vitro. The broad-spectrum activity of the compound indicates a host protein may be the target. It does not effect nucleic acid transcription, but does inhibit early and late protein translation in HCMV. A potential molecular target, HSPBeta1 (Hsp27), was identified by co-precipitation pulldown assay.}, url = {http://digitalcollections.ohsu.edu/record/9619}, doi = {https://doi.org/10.6083/8g84mm88k}, }