TY  - GEN
N2  - This is a basic science project to study the mechanism of a novel, broad-spectrum antiviral small molecule series. The small molecule series, SR-33001, inhibits Herpes, Alpha, and Flavi viruses in vitro. The broad-spectrum activity of the compound indicates a host protein may be the target. It does not effect nucleic acid transcription, but does inhibit early and late protein translation in HCMV. A potential molecular target, HSPBeta1 (Hsp27), was identified by co-precipitation pulldown assay.
DO  - 10.6083/8g84mm88k
DO  - DOI
AB  - This is a basic science project to study the mechanism of a novel, broad-spectrum antiviral small molecule series. The small molecule series, SR-33001, inhibits Herpes, Alpha, and Flavi viruses in vitro. The broad-spectrum activity of the compound indicates a host protein may be the target. It does not effect nucleic acid transcription, but does inhibit early and late protein translation in HCMV. A potential molecular target, HSPBeta1 (Hsp27), was identified by co-precipitation pulldown assay.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Characterizing a novel, broad spectrum antiviral small molecule
ED  - Streblow, Daniel
ED  - Mentor
DA  - 2022
AU  - Pommert, Kathleen
AU  - Alexander, Timothy
AU  - Haese, Nicole
L1  - https://digitalcollections.ohsu.edu/record/9619/files/Pommert.Kathleen.CaptionWeek.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9619
L4  - https://digitalcollections.ohsu.edu/record/9619/files/Pommert.Kathleen.CaptionWeek.2022.pdf
KW  - mechanism
KW  - target
KW  - broad-spectrum
KW  - hcmv
KW  - antiviral
KW  - hsp27
TI  - Characterizing a novel, broad spectrum antiviral small molecule
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9619/files/Pommert.Kathleen.CaptionWeek.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9619/files/Pommert.Kathleen.CaptionWeek.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9619/files/Pommert.Kathleen.CaptionWeek.2022.pdf
ER  -