000009619 001__ 9619
000009619 005__ 20240125143601.0
000009619 0247_ $$2DOI$$a10.6083/8g84mm88k
000009619 037__ $$aIR
000009619 245__ $$aCharacterizing a novel, broad spectrum antiviral small molecule
000009619 260__ $$bOregon Health and Science University
000009619 269__ $$a2022
000009619 336__ $$aCapstone
000009619 502__ $$gMedicine (Undergraduate Medical Education)
000009619 502__ $$bM.D.
000009619 520__ $$aThis is a basic science project to study the mechanism of a novel, broad-spectrum antiviral small molecule series. The small molecule series, SR-33001, inhibits Herpes, Alpha, and Flavi viruses in vitro. The broad-spectrum activity of the compound indicates a host protein may be the target. It does not effect nucleic acid transcription, but does inhibit early and late protein translation in HCMV. A potential molecular target, HSPBeta1 (Hsp27), was identified by co-precipitation pulldown assay.
000009619 540__ $$fCC BY
000009619 6531_ $$amechanism
000009619 6531_ $$atarget
000009619 6531_ $$abroad-spectrum
000009619 6531_ $$ahcmv
000009619 6531_ $$aantiviral
000009619 6531_ $$ahsp27
000009619 691__ $$aSchool of Medicine$$041369
000009619 7001_ $$aPommert, Kathleen$$uOregon Health and Science University$$041354
000009619 7001_ $$aAlexander, Timothy$$uOregon Health and Science University$$041354
000009619 7001_ $$aHaese, Nicole$$uOregon Health and Science University$$041354
000009619 7201_ $$aStreblow, Daniel$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000009619 8564_ $$99d9775d8-b32f-4815-9700-72ec7c0dc717$$s1212968$$uhttps://digitalcollections.ohsu.edu/record/9619/files/Pommert.Kathleen.CaptionWeek.2022.pdf
000009619 905__ $$a/rest/prod/8g/84/mm/88/8g84mm88k
000009619 909CO $$ooai:digitalcollections.ohsu.edu:9619$$pstudent-work
000009619 980__ $$aScholarly Project Capstones