@article{IR,
      author = {Nilaver, Benjamin and Thomas, Jeremy and Appleman,  Maria-Luisa and Kohama, Steven G. and Urbanski, Henryk F.},
      url = {http://digitalcollections.ohsu.edu/record/9620},
      title = {Macaques exhibit TDP-43 morphology comparable to human  aging and dementia},
      publisher = {Oregon Health and Science University},
      abstract = {Transactive response DNA binding protein of 43 kDa  (TDP-43) is a ubiquitously expressed nuclear protein  involved in RNA metabolism and stress granule formation.  Pathological inclusions and mislocalization of this protein  in brain cells is pathognomonic or concurrent across a wide  range of neurodegenerative diseases, and has been  implicated in age-associated cognitive decline. In these  pathologies, TDP-43 becomes mislocalized, forming  inclusions in the cytoplasm, nucleus, and cell processes.  In these inclusions, TDP-43 undergoes aberrant  post-translational modifications, often phosphorylation.  This investigation assessed the presence of TDP-43  pathology and mislocalization in the amygdala, entorhinal  cortex, and prefrontal cortex of aged rhesus macaques.  Endogenous TDP-43 pathology in the macaque brain has not  been well described. We hypothesized that the macaque  exhibits histological TDP-43 phenotypes resembling those  found in human neurodegeneration and cognitive decline.},
      number = {IR},
      doi = {https://doi.org/10.6083/hm50ts51n},
      recid = {9620},
      address = {2022-04-14},
}