TY  - GEN
N2  - Transactive response DNA binding protein of 43 kDa (TDP-43) is a ubiquitously expressed nuclear protein involved in RNA metabolism and stress granule formation. Pathological inclusions and mislocalization of this protein in brain cells is pathognomonic or concurrent across a wide range of neurodegenerative diseases, and has been implicated in age-associated cognitive decline. In these pathologies, TDP-43 becomes mislocalized, forming inclusions in the cytoplasm, nucleus, and cell processes. In these inclusions, TDP-43 undergoes aberrant post-translational modifications, often phosphorylation. This investigation assessed the presence of TDP-43 pathology and mislocalization in the amygdala, entorhinal cortex, and prefrontal cortex of aged rhesus macaques. Endogenous TDP-43 pathology in the macaque brain has not been well described. We hypothesized that the macaque exhibits histological TDP-43 phenotypes resembling those found in human neurodegeneration and cognitive decline.
DO  - 10.6083/hm50ts51n
DO  - DOI
AB  - Transactive response DNA binding protein of 43 kDa (TDP-43) is a ubiquitously expressed nuclear protein involved in RNA metabolism and stress granule formation. Pathological inclusions and mislocalization of this protein in brain cells is pathognomonic or concurrent across a wide range of neurodegenerative diseases, and has been implicated in age-associated cognitive decline. In these pathologies, TDP-43 becomes mislocalized, forming inclusions in the cytoplasm, nucleus, and cell processes. In these inclusions, TDP-43 undergoes aberrant post-translational modifications, often phosphorylation. This investigation assessed the presence of TDP-43 pathology and mislocalization in the amygdala, entorhinal cortex, and prefrontal cortex of aged rhesus macaques. Endogenous TDP-43 pathology in the macaque brain has not been well described. We hypothesized that the macaque exhibits histological TDP-43 phenotypes resembling those found in human neurodegeneration and cognitive decline.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Macaques exhibit TDP-43 morphology comparable to human aging and dementia
DA  - 2022-04-14
AU  - Nilaver, Benjamin
AU  - Thomas, Jeremy
AU  - Appleman, Maria-Luisa
AU  - Kohama, Steven G.
AU  - Urbanski, Henryk F.
L1  - https://digitalcollections.ohsu.edu/record/9620/files/Nilaver-Benjamin-ResearchWeek2022.pdf
PB  - Oregon Health and Science University
PY  - 2022-04-14
ID  - 9620
L4  - https://digitalcollections.ohsu.edu/record/9620/files/Nilaver-Benjamin-ResearchWeek2022.pdf
KW  - Immunohistochemistry
KW  - Histology
KW  - Dementia
KW  - Aging
KW  - Neuropathology
KW  - Macaca mulatta
KW  - Models, Animal
KW  - TDP-43 Proteinopathies
TI  - Macaques exhibit TDP-43 morphology comparable to human aging and dementia
Y1  - 2022-04-14
L2  - https://digitalcollections.ohsu.edu/record/9620/files/Nilaver-Benjamin-ResearchWeek2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9620/files/Nilaver-Benjamin-ResearchWeek2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9620/files/Nilaver-Benjamin-ResearchWeek2022.pdf
ER  -