000009620 001__ 9620
000009620 005__ 20240411123111.0
000009620 0247_ $$2DOI$$a10.6083/hm50ts51n
000009620 037__ $$aIR
000009620 245__ $$aMacaques exhibit TDP-43 morphology comparable to human aging and dementia
000009620 260__ $$bOregon Health and Science University
000009620 269__ $$a2022-04-14
000009620 336__ $$aAbstract
000009620 520__ $$aTransactive response DNA binding protein of 43 kDa (TDP-43) is a ubiquitously expressed nuclear protein involved in RNA metabolism and stress granule formation. Pathological inclusions and mislocalization of this protein in brain cells is pathognomonic or concurrent across a wide range of neurodegenerative diseases, and has been implicated in age-associated cognitive decline. In these pathologies, TDP-43 becomes mislocalized, forming inclusions in the cytoplasm, nucleus, and cell processes. In these inclusions, TDP-43 undergoes aberrant post-translational modifications, often phosphorylation. This investigation assessed the presence of TDP-43 pathology and mislocalization in the amygdala, entorhinal cortex, and prefrontal cortex of aged rhesus macaques. Endogenous TDP-43 pathology in the macaque brain has not been well described. We hypothesized that the macaque exhibits histological TDP-43 phenotypes resembling those found in human neurodegeneration and cognitive decline.
000009620 540__ $$fCC BY
000009620 542__ $$fIn copyright - joint owners
000009620 650__ $$aImmunohistochemistry$$020708
000009620 650__ $$aHistology$$020244
000009620 650__ $$aDementia$$017461
000009620 650__ $$aAging$$014358
000009620 650__ $$aNeuropathology$$011381
000009620 650__ $$aMacaca mulatta$$021724
000009620 650__ $$aModels, Animal$$033025
000009620 650__ $$aTDP-43 Proteinopathies$$038880
000009620 692__ $$aOregon National Primate Research Center$$041497
000009620 7001_ $$aNilaver, Benjamin$$uOregon Health and Science University$$041354
000009620 7001_ $$aThomas, Jeremy$$uOregon Health and Science University$$041354
000009620 7001_ $$aAppleman, Maria-Luisa$$uOregon Health and Science University$$041354
000009620 7001_ $$aKohama, Steven G.$$uOregon Health and Science University$$041354
000009620 7001_ $$aUrbanski, Henryk F.$$uOregon Health and Science University$$041354
000009620 711__ $$aResearch Week$$uOregon Health and Science University$$d2022
000009620 8564_ $$9a6522086-b4b2-40fb-b25d-869975821aed$$s181759$$uhttps://digitalcollections.ohsu.edu/record/9620/files/Nilaver-Benjamin-ResearchWeek2022.pdf
000009620 905__ $$a/rest/prod/hm/50/ts/51/hm50ts51n
000009620 980__ $$aResearch Week