@article{ETD,
      school = {Ph.D.},
      author = {Helms, Erin J.},
      url = {http://digitalcollections.ohsu.edu/record/9630},
      title = {Mesenchymal cells of distinct lineages have unique  functions in the PDAC microenvironment with implications  for treatment efficacy},
      publisher = {Oregon Health and Science University},
      abstract = {The grim prognosis for pancreatic ductal adenocarcinoma  (PDAC) patients impels an improved understanding of disease  biology to facilitate the development of enhanced  therapies. PDAC often features a remarkably dense stroma  established and populated by a pronounced population of  cancer associated fibroblasts (CAFs). The overall  hypothesis of this dissertation is that pancreatic stellate  cells activate to a fibroblast phenotype that plays a  significant role in the ECM and tissue stiffness of PDAC.  To evaluate this hypothesis we used mouse models, isolated  cultured cells, and patient tumor samples as well as  clinical RNA sequencing data from PDAC patients. The  following chapters will address the following three aims.},
      number = {ETD},
      doi = {https://doi.org/10.6083/5x21tg304},
      recid = {9630},
      address = {2022},
}