TY  - THES
N2  - The grim prognosis for pancreatic ductal adenocarcinoma (PDAC) patients impels an improved understanding of disease biology to facilitate the development of enhanced therapies. PDAC often features a remarkably dense stroma established and populated by a pronounced population of cancer associated fibroblasts (CAFs). The overall hypothesis of this dissertation is that pancreatic stellate cells activate to a fibroblast phenotype that plays a significant role in the ECM and tissue stiffness of PDAC. To evaluate this hypothesis we used mouse models, isolated cultured cells, and patient tumor samples as well as clinical RNA sequencing data from PDAC patients. The following chapters will address the following three aims.
DO  - 10.6083/5x21tg304
DO  - DOI
AB  - The grim prognosis for pancreatic ductal adenocarcinoma (PDAC) patients impels an improved understanding of disease biology to facilitate the development of enhanced therapies. PDAC often features a remarkably dense stroma established and populated by a pronounced population of cancer associated fibroblasts (CAFs). The overall hypothesis of this dissertation is that pancreatic stellate cells activate to a fibroblast phenotype that plays a significant role in the ECM and tissue stiffness of PDAC. To evaluate this hypothesis we used mouse models, isolated cultured cells, and patient tumor samples as well as clinical RNA sequencing data from PDAC patients. The following chapters will address the following three aims.
T1  - Mesenchymal cells of distinct lineages have unique functions in the PDAC microenvironment with implications for treatment efficacy
DA  - 2022
AU  - Helms, Erin J.
L1  - https://digitalcollections.ohsu.edu/record/9630/files/Helms.Erin.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9630
L4  - https://digitalcollections.ohsu.edu/record/9630/files/Helms.Erin.2022.pdf
KW  - Extracellular Matrix
KW  - fabp4
KW  - fibroblast
KW  - pancreatic stellate cell
KW  - pancreatic ductal adenocarcinoma
KW  - stroma
TI  - Mesenchymal cells of distinct lineages have unique functions in the PDAC microenvironment with implications for treatment efficacy
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9630/files/Helms.Erin.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9630/files/Helms.Erin.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9630/files/Helms.Erin.2022.pdf
ER  -