000009630 001__ 9630
000009630 005__ 20240124114326.0
000009630 0247_ $$2DOI$$a10.6083/5x21tg304
000009630 037__ $$aETD
000009630 245__ $$aMesenchymal cells of distinct lineages have unique functions in the PDAC microenvironment with implications for treatment efficacy
000009630 260__ $$bOregon Health and Science University
000009630 269__ $$a2022
000009630 336__ $$aThesis
000009630 502__ $$bPh.D.
000009630 520__ $$aThe grim prognosis for pancreatic ductal adenocarcinoma (PDAC) patients impels an improved understanding of disease biology to facilitate the development of enhanced therapies. PDAC often features a remarkably dense stroma established and populated by a pronounced population of cancer associated fibroblasts (CAFs). The overall hypothesis of this dissertation is that pancreatic stellate cells activate to a fibroblast phenotype that plays a significant role in the ECM and tissue stiffness of PDAC. To evaluate this hypothesis we used mouse models, isolated cultured cells, and patient tumor samples as well as clinical RNA sequencing data from PDAC patients. The following chapters will address the following three aims.
000009630 650__ $$aExtracellular Matrix$$018796
000009630 6531_ $$afabp4
000009630 6531_ $$afibroblast
000009630 6531_ $$apancreatic stellate cell
000009630 6531_ $$apancreatic ductal adenocarcinoma
000009630 6531_ $$astroma
000009630 691__ $$aSchool of Medicine$$041369
000009630 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000009630 7001_ $$aHelms, Erin J.
000009630 8564_ $$943de6a6f-87ee-44fb-bcaa-700404b1be72$$s5005269$$uhttps://digitalcollections.ohsu.edu/record/9630/files/Helms.Erin.2022.pdf
000009630 905__ $$a/rest/prod/5x/21/tg/30/5x21tg304
000009630 909CO $$ooai:digitalcollections.ohsu.edu:9630$$pstudent-work
000009630 980__ $$aTheses and Dissertations