000009642 001__ 9642 000009642 005__ 20240412110731.0 000009642 0247_ $$2DOI$$a10.6083/w37637734 000009642 037__ $$aIR 000009642 245__ $$aModulatory role of apremilast on binge-like drinking and brain cytokine levels 000009642 260__ $$bOregon Health and Science University 000009642 269__ $$a2022-04-22 000009642 336__ $$aAbstract 000009642 520__ $$aOur understanding of the neuroimmune response to alcohol exposure and its role in the development and maintenance of Alcohol Use Disorder (AUD) has provided an avenue for discovering potential pharmacotherapies. We tested 28 compounds (many of which target inflammatory processes) for their ability to reduce drinking in High Drinking in the Dark mice (HDID), a unique genetic model of drinking to intoxication. Many (11 out of 14) compounds that reduced binge-like drinking in HDID mice had one thing in common; they increased anti-inflammatory signaling in the periphery. We found that apremilast, an FDA approved phosphodiesterase type 4 (PDE4) and tumor necrosis factor alpha (TNFa) inhibitor used for the treatment of psoriasis, significantly reduced binge-like drinking and blood alcohol levels in both HDID-1 and HDID-2 mice (0, 20, 40mg/kg; n=11- 13/sex/line/dose; p's < 0.05 for all). 000009642 536__ $$oOregon Health and Science University$$c01 AA013519 000009642 536__ $$oNational Institute of Health$$cP60 AA010760 000009642 536__ $$oDepartment of Veterans Affairs$$cIK2 BX004699 000009642 540__ $$fCC BY 000009642 542__ $$fIn copyright - joint owners 000009642 650__ $$aBinge Drinking$$040232 000009642 6531_ $$ainflammatory signaling 000009642 6531_ $$aapremilast 000009642 691__ $$aSchool of Medicine$$041369 000009642 692__ $$aDepartment of Behavioral Neuroscience$$041394 000009642 7001_ $$aMedrano, J.$$uOregon Health and Science University$$041354 000009642 7001_ $$aGrigsby, K.$$uOregon Health and Science University$$041354 000009642 7001_ $$aOzburn, A.$$uOregon Health and Science University$$041354 000009642 711__ $$aResearch Week$$uOregon Health and Science University$$d2022 000009642 8564_ $$9f1a030e5-7793-4a3a-98cd-4ea8795f5819$$s68387$$uhttps://digitalcollections.ohsu.edu/record/9642/files/ResearchWeek2022-AbstractTemplate_for_IR__6_.pdf 000009642 905__ $$a/rest/prod/w3/76/37/73/w37637734 000009642 980__ $$aResearch Week