000000967 001__ 967 000000967 005__ 20250424232559.0 000000967 0247_ $$2DOI$$a10.6083/M4NV9G84 000000967 037__ $$aETD 000000967 245__ $$aIdentification of critical pathways altered by radiation exposure and drug target analysis 000000967 260__ $$bOregon Health and Science University 000000967 269__ $$a2013 000000967 336__ $$aThesis 000000967 502__ $$bM.S. 000000967 502__ $$gBioinformatics & Computational Biomedicine 000000967 520__ $$aIonizing radiation (IR) is frequently used in the treatment of cancer through radiation therapy. However, exposure to IR also poses a significant safety risk for nuclear workers. The impact of IR on human cells, both normal and cancerous, is biologically important. This study has three main objectives: 1) to identify which genes are differentially expressed in cells exposed to radiation, 2) to uncover critical pathways influenced by these genes, and 3) to determine which drugs effectively target the differentially expressed pathways. 000000967 540__ $$fCC BY 000000967 542__ $$fIn copyright - single owner 000000967 650__ $$aDNA Fingerprinting$$028933 000000967 650__ $$aDrug Delivery Systems$$029171 000000967 650__ $$aOligonucleotides$$023188 000000967 650__ $$aOligonucleotide Array Sequence Analysis$$032398 000000967 650__ $$aGene Expression$$028717 000000967 650__ $$aRadiation Tolerance$$025075 000000967 650__ $$aGene Expression Profiling$$032769 000000967 650__ $$aRadiation Exposure$$011344 000000967 650__ $$aNeoplasms 000000967 650__ $$aRadiation, Ionizing$$025078 000000967 650__ $$aCritical Pathways$$031348 000000967 6531_ $$anucleotide sequence 000000967 6531_ $$adrug targeting 000000967 691__ $$aSchool of Medicine$$041369 000000967 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422 000000967 7001_ $$aBetzing, Christopher$$uOregon Health and Science University$$041354 000000967 7201_ $$aBoudreau, Eilis$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor 000000967 8564_ $$9536fd351-26d2-446c-9a20-b92b8d054d1d$$s776281$$uhttps://digitalcollections.ohsu.edu/record/967/files/970_etd.pdf$$ePublic$$2e22f7da88bcd1370ec25c43bfbc7f69f$$31 000000967 905__ $$a/rest/prod/4m/90/dv/53/4m90dv53k 000000967 909CO $$ooai:digitalcollections.ohsu.edu:967$$pstudent-work 000000967 980__ $$aBiomedical Informatics