TY - GEN AB - The hair bundle, an exquisitely structured organelle of filamentous actin-based protrusions, mediates the transduction of sound into electrochemical signals, thus enabling the sense of hearing. The correct assembly of the bundle during development is therefore essential to hearing. This dissertation examines the contribution of a novel mouse deafness gene, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (Baiap2l2), to bundle maintenance and function. Altogether, this dissertation deepens the understanding of the molecular underpinnings of bundle assembly by adding BAIAP2L2 as an essential factor for bundle stability and by providing evidence for Ca2+ as a mediator of how transduction modulates bundle proteins. AD - Oregon Health and Science University AU - Halford, Julia B. DA - 2022 DO - 10.6083/bg257f77q DO - DOI ID - 9686 KW - Mice KW - Transducers KW - Stereocilia KW - Membrane Proteins KW - Deafness KW - auditory hair cells KW - cell development L1 - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf L2 - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf L4 - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf LK - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf N2 - The hair bundle, an exquisitely structured organelle of filamentous actin-based protrusions, mediates the transduction of sound into electrochemical signals, thus enabling the sense of hearing. The correct assembly of the bundle during development is therefore essential to hearing. This dissertation examines the contribution of a novel mouse deafness gene, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (Baiap2l2), to bundle maintenance and function. Altogether, this dissertation deepens the understanding of the molecular underpinnings of bundle assembly by adding BAIAP2L2 as an essential factor for bundle stability and by providing evidence for Ca2+ as a mediator of how transduction modulates bundle proteins. PB - Oregon Health and Science University PY - 2022 T1 - Characterizing the mouse deafness gene BAIAP2L2 TI - Characterizing the mouse deafness gene BAIAP2L2 UR - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf Y1 - 2022 ER -