TY  - GEN
N2  - The hair bundle, an exquisitely structured organelle of filamentous actin-based protrusions, mediates the transduction of sound into electrochemical signals, thus enabling the sense of hearing. The correct assembly of the bundle during development is therefore essential to hearing. This dissertation examines the contribution of a novel mouse deafness gene, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (Baiap2l2), to bundle maintenance and function. Altogether, this dissertation deepens the understanding of the molecular underpinnings of bundle assembly by adding BAIAP2L2 as an essential factor for bundle stability and by providing evidence for Ca2+ as a mediator of how transduction modulates bundle proteins.
DO  - 10.6083/bg257f77q
DO  - DOI
AB  - The hair bundle, an exquisitely structured organelle of filamentous actin-based protrusions, mediates the transduction of sound into electrochemical signals, thus enabling the sense of hearing. The correct assembly of the bundle during development is therefore essential to hearing. This dissertation examines the contribution of a novel mouse deafness gene, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (Baiap2l2), to bundle maintenance and function. Altogether, this dissertation deepens the understanding of the molecular underpinnings of bundle assembly by adding BAIAP2L2 as an essential factor for bundle stability and by providing evidence for Ca2+ as a mediator of how transduction modulates bundle proteins.
T1  - Characterizing the mouse deafness gene BAIAP2L2
DA  - 2022
AU  - Halford, Julia B.
L1  - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9686
L4  - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf
KW  - Mice
KW  - Transducers
KW  - Stereocilia
KW  - Membrane Proteins
KW  - Deafness
KW  - auditory hair cells
KW  - cell development
TI  - Characterizing the mouse deafness gene BAIAP2L2
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf
ER  -