000009686 001__ 9686 000009686 005__ 20241111143438.0 000009686 0247_ $$2DOI$$a10.6083/bg257f77q 000009686 037__ $$aETD 000009686 245__ $$aCharacterizing the mouse deafness gene BAIAP2L2 000009686 260__ $$bOregon Health and Science University 000009686 269__ $$a2022 000009686 336__ $$aDissertation 000009686 502__ $$bPh.D. 000009686 520__ $$aThe hair bundle, an exquisitely structured organelle of filamentous actin-based protrusions, mediates the transduction of sound into electrochemical signals, thus enabling the sense of hearing. The correct assembly of the bundle during development is therefore essential to hearing. This dissertation examines the contribution of a novel mouse deafness gene, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (Baiap2l2), to bundle maintenance and function. Altogether, this dissertation deepens the understanding of the molecular underpinnings of bundle assembly by adding BAIAP2L2 as an essential factor for bundle stability and by providing evidence for Ca2+ as a mediator of how transduction modulates bundle proteins. 000009686 542__ $$fIn copyright - single owner 000009686 650__ $$aMice$$036842 000009686 650__ $$aTransducers$$027257 000009686 650__ $$aStereocilia$$039594 000009686 650__ $$aMembrane Proteins$$022009 000009686 650__ $$aDeafness$$017398 000009686 6531_ $$aauditory hair cells 000009686 6531_ $$acell development 000009686 691__ $$aSchool of Medicine$$041369 000009686 7001_ $$aHalford, Julia B.$$uOregon Health and Science University$$041354 000009686 8564_ $$9e63760e4-4620-47d5-ab6c-35ce58af10a5$$s6980165$$uhttps://digitalcollections.ohsu.edu/record/9686/files/Halford.Julia.2022.pdf 000009686 905__ $$a/rest/prod/bg/25/7f/77/bg257f77q 000009686 909CO $$ooai:digitalcollections.ohsu.edu:9686$$pstudent-work 000009686 980__ $$aTheses and Dissertations