TY  - GEN
N2  - Sympathetic nerves are lost in the damaged myocardium (infarct) after myocardial infarction (MI), and the relative area of denervation predicts risk of sudden cardiac arrest due to arrhythmias leading to the hypothesis that sympathetic reinnervation of the infarct could reduce arrhythmias. This dissertation also describes an attempt to use genetically encoded FRET-biosensors to understand signaling pathways downstream ofTrkA altered by CSPGs. Due to a number of technological challenges, we limited our assessment to Protein Kinase A (PKA) and Protein Kinase C (PKC) sensors in primary sympathetic neurons but we did not observe any significant responses to CSPGs.
DO  - 10.6083/5425kb45p
DO  - DOI
AB  - Sympathetic nerves are lost in the damaged myocardium (infarct) after myocardial infarction (MI), and the relative area of denervation predicts risk of sudden cardiac arrest due to arrhythmias leading to the hypothesis that sympathetic reinnervation of the infarct could reduce arrhythmias. This dissertation also describes an attempt to use genetically encoded FRET-biosensors to understand signaling pathways downstream ofTrkA altered by CSPGs. Due to a number of technological challenges, we limited our assessment to Protein Kinase A (PKA) and Protein Kinase C (PKC) sensors in primary sympathetic neurons but we did not observe any significant responses to CSPGs.
T1  - Chondroitin sulfate proteoglycan sulfation patterns prevent sympathetic nerve regeneration after myocardial infarction
DA  - 2022
AU  - Blake, Matthew R.
L1  - https://digitalcollections.ohsu.edu/record/9690/files/Blake.Matthew.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9690
L4  - https://digitalcollections.ohsu.edu/record/9690/files/Blake.Matthew.2022.pdf
KW  - Heart Failure
KW  - Neuronal Outgrowth
KW  - Extracellular Matrix
KW  - Nerve Regeneration
KW  - Myocardial Infarction
TI  - Chondroitin sulfate proteoglycan sulfation patterns prevent sympathetic nerve regeneration after myocardial infarction
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9690/files/Blake.Matthew.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9690/files/Blake.Matthew.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9690/files/Blake.Matthew.2022.pdf
ER  -