@article{ETD, recid = {9705}, author = {Schoen, Devin}, title = {Investigating the feasibility of using a population-based input function for pharmacokinetic modeling of [11C]PBR28 during positron emission tomography studies in a population of methamphetamine users}, publisher = {Oregon Health and Science University}, school = {M.S.}, address = {2022}, number = {ETD}, abstract = {The innate neuroimmune response is characterized, in part, by proliferation and morphological changes of microglia and astrocytes. Over-activation of microglia results in the production of a number of pro-inflammatory markers and the release of reactive oxygen and nitrogen species that cause neuronal damage. The aims of this thesis were to investigate if there is a significant difference in the tracer plasma concentrations between healthy controls (HC) and MA users and to identify an alternative to arterial Ifs by generating a population-based input functions (PBIF).}, url = {http://digitalcollections.ohsu.edu/record/9705}, doi = {https://doi.org/10.6083/7h149q66x}, }