TY  - THES
N2  - The innate neuroimmune response is characterized, in part, by proliferation and morphological changes of microglia and astrocytes. Over-activation of microglia results in the production of a number of pro-inflammatory markers and the release of reactive oxygen and nitrogen species that cause neuronal damage. The aims of this thesis were to investigate if there is a significant difference in the tracer plasma concentrations between healthy controls (HC) and MA users and to identify an alternative to arterial Ifs by generating a population-based input functions (PBIF).
DO  - 10.6083/7h149q66x
DO  - DOI
AB  - The innate neuroimmune response is characterized, in part, by proliferation and morphological changes of microglia and astrocytes. Over-activation of microglia results in the production of a number of pro-inflammatory markers and the release of reactive oxygen and nitrogen species that cause neuronal damage. The aims of this thesis were to investigate if there is a significant difference in the tracer plasma concentrations between healthy controls (HC) and MA users and to identify an alternative to arterial Ifs by generating a population-based input functions (PBIF).
T1  - Investigating the feasibility of using a population-based input function for pharmacokinetic modeling of [11C]PBR28 during positron emission tomography studies in a population of methamphetamine users
DA  - 2022
AU  - Schoen, Devin
L1  - https://digitalcollections.ohsu.edu/record/9705/files/Schoen.Devin.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9705
L4  - https://digitalcollections.ohsu.edu/record/9705/files/Schoen.Devin.2022.pdf
KW  - Neuroinflammatory Diseases
KW  - Methamphetamine
KW  - Positron-Emission Tomography
KW  - Drug Users
KW  - intravenous substance abuse
KW  - pharmacokinetic modeling
TI  - Investigating the feasibility of using a population-based input function for pharmacokinetic modeling of [11C]PBR28 during positron emission tomography studies in a population of methamphetamine users
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9705/files/Schoen.Devin.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9705/files/Schoen.Devin.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9705/files/Schoen.Devin.2022.pdf
ER  -