000009705 001__ 9705
000009705 005__ 20240124114328.0
000009705 0247_ $$2DOI$$a10.6083/7h149q66x
000009705 037__ $$aETD
000009705 245__ $$aInvestigating the feasibility of using a population-based input function for pharmacokinetic modeling of [11C]PBR28 during positron emission tomography studies in a population of methamphetamine users
000009705 260__ $$bOregon Health and Science University
000009705 269__ $$a2022
000009705 336__ $$aThesis
000009705 502__ $$bM.S.
000009705 520__ $$aThe innate neuroimmune response is characterized, in part, by proliferation and morphological changes of microglia and astrocytes. Over-activation of microglia results in the production of a number of pro-inflammatory markers and the release of reactive oxygen and nitrogen species that cause neuronal damage. The aims of this thesis were to investigate if there is a significant difference in the tracer plasma concentrations between healthy controls (HC) and MA users and to identify an alternative to arterial Ifs by generating a population-based input functions (PBIF).
000009705 650__ $$aNeuroinflammatory Diseases$$013756
000009705 650__ $$aMethamphetamine$$022135
000009705 650__ $$aPositron-Emission Tomography$$036178
000009705 650__ $$aDrug Users$$038136
000009705 6531_ $$aintravenous substance abuse
000009705 6531_ $$apharmacokinetic modeling
000009705 691__ $$aSchool of Medicine$$041369
000009705 7001_ $$aSchoen, Devin
000009705 8564_ $$99271a479-ec57-475d-8be6-f4bd50e7ae2b$$s2338456$$uhttps://digitalcollections.ohsu.edu/record/9705/files/Schoen.Devin.2022.pdf
000009705 905__ $$a/rest/prod/7h/14/9q/66/7h149q66x
000009705 909CO $$ooai:digitalcollections.ohsu.edu:9705$$pstudent-work
000009705 980__ $$aTheses and Dissertations