@article{ETD,
      school = {Ph.D.},
      author = {Van Winkle, Jacob A.},
      url = {http://digitalcollections.ohsu.edu/record/9716},
      title = {Characterizing the dominant role of interferon-lambda  (IFN-λ) signaling in the intestinal epithelium},
      publisher = {Oregon Health and Science University},
      abstract = {Interferon (IFN) family cytokines stimulate a broad group  of genes known as interferon stimulated gene (ISGs). The  primary function of ISGs is to provide antiviral host  defense. IFN-α and IFN-β signal through IFN-α receptor  (IFNAR) whereas IFN-λ signals through IFN-λ receptor  (IFNLR). IFNAR is expressed by many cell types, but IFNLR  is primarily expressed by epithelial cells in barrier  tissues. However, unlike most 
epithelial barriers that  respond to both IFN-λ and IFN-α/β, intestinal epithelial  cells (IECs) preferentially respond to IFN-λ and are  hyporesponsive to IFN-α/β. As such, IFN-λ has a dominant  role in protecting IECs from enteric viruses. The  physiological rationale for this selective responsiveness  by IECs is poorly understood. Furthermore, the interactions  of IFN-λ signaling in  IECs  with  the  environmental   context  of  bacterial  microbiota  have  not been  determined. In this dissertation, I describe the  consequences and contexts surrounding the IFN-λ response  by IECs.},
      number = {ETD},
      doi = {https://doi.org/10.6083/v979v391t},
      recid = {9716},
      address = {2022},
}