TY  - GEN
N2  - Interferon (IFN) family cytokines stimulate a broad group of genes known as interferon stimulated gene (ISGs). The primary function of ISGs is to provide antiviral host defense. IFN-α and IFN-β signal through IFN-α receptor (IFNAR) whereas IFN-λ signals through IFN-λ receptor (IFNLR). IFNAR is expressed by many cell types, but IFNLR is primarily expressed by epithelial cells in barrier tissues. However, unlike most 
epithelial barriers that respond to both IFN-λ and IFN-α/β, intestinal epithelial cells (IECs) preferentially respond to IFN-λ and are hyporesponsive to IFN-α/β. As such, IFN-λ has a dominant role in protecting IECs from enteric viruses. The physiological rationale for this selective responsiveness by IECs is poorly understood. Furthermore, the interactions of IFN-λ signaling in  IECs  with  the  environmental  context  of  bacterial  microbiota  have  not been determined. In this dissertation, I describe the consequences and contexts surrounding the IFN-λ response by IECs.
DO  - 10.6083/v979v391t
DO  - DOI
AB  - Interferon (IFN) family cytokines stimulate a broad group of genes known as interferon stimulated gene (ISGs). The primary function of ISGs is to provide antiviral host defense. IFN-α and IFN-β signal through IFN-α receptor (IFNAR) whereas IFN-λ signals through IFN-λ receptor (IFNLR). IFNAR is expressed by many cell types, but IFNLR is primarily expressed by epithelial cells in barrier tissues. However, unlike most 
epithelial barriers that respond to both IFN-λ and IFN-α/β, intestinal epithelial cells (IECs) preferentially respond to IFN-λ and are hyporesponsive to IFN-α/β. As such, IFN-λ has a dominant role in protecting IECs from enteric viruses. The physiological rationale for this selective responsiveness by IECs is poorly understood. Furthermore, the interactions of IFN-λ signaling in  IECs  with  the  environmental  context  of  bacterial  microbiota  have  not been determined. In this dissertation, I describe the consequences and contexts surrounding the IFN-λ response by IECs.
T1  - Characterizing the dominant role of interferon-lambda (IFN-λ) signaling in the intestinal epithelium
DA  - 2022
AU  - Van Winkle, Jacob A.
L1  - https://digitalcollections.ohsu.edu/record/9716/files/VanWinkle.Jacob.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9716
L4  - https://digitalcollections.ohsu.edu/record/9716/files/VanWinkle.Jacob.2022.pdf
KW  - Intestinal Mucosa
KW  - Epithelial Cells
KW  - Interferons
KW  - Rotavirus
KW  - Gastrointestinal Microbiome
KW  - Organoids
KW  - Tumor Necrosis Factor-alpha
TI  - Characterizing the dominant role of interferon-lambda (IFN-λ) signaling in the intestinal epithelium
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9716/files/VanWinkle.Jacob.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9716/files/VanWinkle.Jacob.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9716/files/VanWinkle.Jacob.2022.pdf
ER  -