000009717 001__ 9717
000009717 005__ 20231129124951.0
000009717 0247_ $$2DOI$$a10.6083/ff3656199
000009717 037__ $$aETD
000009717 245__ $$aEvaluation of dorsal striatal functional connectivity differences across heavy and non-heavy alcohol drinking rhesus macaques with resting state functional magnetic resonance imaging
000009717 260__ $$bOregon Health and Science University
000009717 269__ $$a2022
000009717 336__ $$aThesis
000009717 502__ $$bM.S.
000009717 520__ $$aResting state functional MRI (rsfMRI) is a novel imaging tool used to indirectly assess the neural activity within the brain. Literature points to a disrup-tion of cortical-subcortical circuitry in alcohol use disorders (AUD). Correlation of individual ethanol drinking averages with intrinsic functional connectivity (FC) may highlight maladaptations within these subcortical structures.The CAU and PUT are striatal structures involved in addiction-related brain circuitry. The PUT is an important structure heavily associated with habitual behaviors (chronic heavy drinking). Prior electrophysiological studies found a de-crease in inhibitory neural transmission to the PUT in HD primates after prolonged consumption. Our results showcase a selective decrease in FC of the dorsal striatum in HD monkeys within the sensorimotor network post-drinking.
000009717 650__ $$aCorpus Striatum$$017127
000009717 650__ $$aMacaca mulatta$$021724
000009717 650__ $$aMagnetic Resonance Imaging$$021747
000009717 650__ $$aAlcoholism$$014412
000009717 691__ $$aSchool of Medicine$$041369
000009717 7001_ $$aRuano Espinoza, Kricia
000009717 8564_ $$9d43f0ed5-76c7-4d9f-8474-f4af7997438b$$s11127450$$uhttps://digitalcollections.ohsu.edu/record/9717/files/RuanoEspinoza.Kricia.2022.pdf
000009717 905__ $$a/rest/prod/ff/36/56/19/ff3656199
000009717 909CO $$ooai:digitalcollections.ohsu.edu:9717$$pstudent-work
000009717 980__ $$aTheses and Dissertations