000000973 001__ 973
000000973 005__ 20260120144841.0
000000973 0247_ $$2DOI$$a10.6083/M4W9576G
000000973 037__ $$aETD
000000973 245__ $$aEnhancement of cediranib anti-angiogenic/anti-tumor efficacy in intracranial mouse glioma
000000973 260__ $$bOregon Health and Science University
000000973 269__ $$a2013
000000973 336__ $$aThesis
000000973 502__ $$bPh.D.
000000973 502__ $$gBiomedical Engineering
000000973 520__ $$aGlioblastoma multiforme (GBM) is the most aggressive glioma, with poor survival despite anti-angiogenic therapy. Resistance mechanisms, including Akt pathway activation and autophagy, limit treatment efficacy. This study evaluated strategies to enhance the receptor tyrosine kinase inhibitor cediranib, which targets VEGF and PDGF receptors. Two novel combinations were tested: cediranib with quinacrine, an autophagy inhibitor, and cediranib with proteasome inhibitor SC68896. Both combinations improved anti-glioma activity in vitro and in vivo, reducing tumor growth and vascularization, increasing necrosis, and prolonging survival. Findings suggest targeting dimerization and survival pathways alongside angiogenesis may offer promising therapeutic approaches for GBM.
000000973 540__ $$fCC BY
000000973 542__ $$fIn copyright - single owner
000000973 650__ $$aQuinazolines$$025041
000000973 650__ $$aAutophagy$$015252
000000973 650__ $$aMagnetic Resonance Imaging$$021747
000000973 650__ $$aProteasome Endopeptidase Complex$$035896
000000973 650__ $$aGlioma$$019548
000000973 650__ $$aTyrosine Protein Kinase Inhibitors$$013842
000000973 650__ $$aTreatment Outcome$$029508
000000973 650__ $$aGlioblastoma$$019547
000000973 650__ $$aProtein-Tyrosine Kinases$$024762
000000973 691__ $$aSchool of Medicine$$041369
000000973 692__ $$aDepartment of Biomedical Engineering$$041397
000000973 7001_ $$aLobo, Merryl$$uOregon Health and Science University$$041354
000000973 7201_ $$aPike, Martin$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000973 8564_ $$96010ac36-6217-4567-889a-d22f9f81ab09$$s38711679$$uhttps://digitalcollections.ohsu.edu/record/973/files/976_etd.pdf$$ePublic$$24e147dc0d1c280d73577cdca552ed5bf$$31
000000973 905__ $$a/rest/prod/zc/77/sq/17/zc77sq17w
000000973 909CO $$ooai:digitalcollections.ohsu.edu:973$$pstudent-work
000000973 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000973 980__ $$aTheses and Dissertations