TY  - GEN
N2  - Cardiovascular diseases (CVD) such as ischemic heart disease and peripheral artery disease, continue to be the leading cause of death worldwide. The primary underlying cause of these diseases is atherosclerosis, the deposition of cholesterol, lipids, and calcium leading to plaque formation within the blood vessel wall, causing thickening and hardening of the tissue and obstruction of blood flow. Implantable medical devices, including vascular grafts and stents, can be used to reintroduce blood flow downstream of the obstructed area. The current gold standard for surgical intervention in CVD is the use of autologous vessels to bypass the obstructed flow. However, patients often lack suitable vessels requiring the use of synthetic graft materials. This dissertation describes novel biomaterials and therapeutics designed for vascular applications for the advancement of cardiovascular medicine.
DO  - 10.6083/gh93h0373
DO  - DOI
AB  - Cardiovascular diseases (CVD) such as ischemic heart disease and peripheral artery disease, continue to be the leading cause of death worldwide. The primary underlying cause of these diseases is atherosclerosis, the deposition of cholesterol, lipids, and calcium leading to plaque formation within the blood vessel wall, causing thickening and hardening of the tissue and obstruction of blood flow. Implantable medical devices, including vascular grafts and stents, can be used to reintroduce blood flow downstream of the obstructed area. The current gold standard for surgical intervention in CVD is the use of autologous vessels to bypass the obstructed flow. However, patients often lack suitable vessels requiring the use of synthetic graft materials. This dissertation describes novel biomaterials and therapeutics designed for vascular applications for the advancement of cardiovascular medicine.
T1  - Engineering novel biomaterials and evaluating the use of novel therapeutics in current clinical devices to mitigate medical device-induced thrombosis
DA  - 2022
AU  - Bates, Novella M.
L1  - https://digitalcollections.ohsu.edu/record/9736/files/Bates.Novella.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9736
L4  - https://digitalcollections.ohsu.edu/record/9736/files/Bates.Novella.2022.pdf
KW  - Cardiovascular Diseases
KW  - Polyvinyl Alcohol
KW  - Vascular Grafting
KW  - Stents
KW  - Biocompatible Materials
KW  - Thrombosis
TI  - Engineering novel biomaterials and evaluating the use of novel therapeutics in current clinical devices to mitigate medical device-induced thrombosis
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9736/files/Bates.Novella.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9736/files/Bates.Novella.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9736/files/Bates.Novella.2022.pdf
ER  -