000009736 001__ 9736
000009736 005__ 20231129124951.0
000009736 0247_ $$2DOI$$a10.6083/gh93h0373
000009736 037__ $$aETD
000009736 245__ $$aEngineering novel biomaterials and evaluating the use of novel therapeutics in current clinical devices to mitigate medical device-induced thrombosis
000009736 260__ $$bOregon Health and Science University
000009736 269__ $$a2022
000009736 336__ $$aDissertation
000009736 502__ $$bPh.D.
000009736 520__ $$aCardiovascular diseases (CVD) such as ischemic heart disease and peripheral artery disease, continue to be the leading cause of death worldwide. The primary underlying cause of these diseases is atherosclerosis, the deposition of cholesterol, lipids, and calcium leading to plaque formation within the blood vessel wall, causing thickening and hardening of the tissue and obstruction of blood flow. Implantable medical devices, including vascular grafts and stents, can be used to reintroduce blood flow downstream of the obstructed area. The current gold standard for surgical intervention in CVD is the use of autologous vessels to bypass the obstructed flow. However, patients often lack suitable vessels requiring the use of synthetic graft materials. This dissertation describes novel biomaterials and therapeutics designed for vascular applications for the advancement of cardiovascular medicine.
000009736 542__ $$fIn copyright - single owner
000009736 650__ $$aCardiovascular Diseases$$016152
000009736 650__ $$aPolyvinyl Alcohol$$024424
000009736 650__ $$aVascular Grafting$$039073
000009736 650__ $$aStents$$028514
000009736 650__ $$aBiocompatible Materials$$015550
000009736 650__ $$aThrombosis$$027034
000009736 691__ $$aSchool of Medicine$$041369
000009736 692__ $$aDepartment of Biomedical Engineering$$041397
000009736 7001_ $$aBates, Novella M.
000009736 8564_ $$965462263-ae0c-4bbb-800c-cdd5d0682820$$s3526262$$uhttps://digitalcollections.ohsu.edu/record/9736/files/Bates.Novella.2022.pdf
000009736 905__ $$a/rest/prod/gh/93/h0/37/gh93h0373
000009736 909CO $$ooai:digitalcollections.ohsu.edu:9736$$pstudent-work
000009736 980__ $$aTheses and Dissertations