TY  - GEN
N2  - While any number of social, psychological, and economic factors contribute to methamphetamine (MA) addiction risk, numerous biological variables have also been identified.The broad goals of this dissertation are to explore the mechanistic correlates of selective breeding for MA intake. The intent of the first aim was to further characterize the receptor encoded by Taar1m1J. Previous work found that this receptor does not produce a cAMP response in the presence of agonist. I build on this by demonstrating the TAAR1 encoded by Taar1m1J binds ligand with drastically reduce affinity. Thus, responses to TAAR1 agonists, such as MA, in these mice are more likely due to impaired ligand binding.  The second aim focused on the hypothermic effects of addictive drugs in the MADR lines.
DO  - 10.6083/3r074v67t
DO  - DOI
AB  - While any number of social, psychological, and economic factors contribute to methamphetamine (MA) addiction risk, numerous biological variables have also been identified.The broad goals of this dissertation are to explore the mechanistic correlates of selective breeding for MA intake. The intent of the first aim was to further characterize the receptor encoded by Taar1m1J. Previous work found that this receptor does not produce a cAMP response in the presence of agonist. I build on this by demonstrating the TAAR1 encoded by Taar1m1J binds ligand with drastically reduce affinity. Thus, responses to TAAR1 agonists, such as MA, in these mice are more likely due to impaired ligand binding.  The second aim focused on the hypothermic effects of addictive drugs in the MADR lines.
T1  - Mechanistic correlates of selective breeding for methamphetamine intake
DA  - 2022
AU  - Mootz, John R. K.
L1  - https://digitalcollections.ohsu.edu/record/9744/files/Mootz.John.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9744
L4  - https://digitalcollections.ohsu.edu/record/9744/files/Mootz.John.2022.pdf
KW  - Methamphetamine
KW  - Genetic Linkage
KW  - Selective Breeding
KW  - drug addiction
KW  - mu opioid receptor
KW  - trace amine receptor 1
TI  - Mechanistic correlates of selective breeding for methamphetamine intake
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9744/files/Mootz.John.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9744/files/Mootz.John.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9744/files/Mootz.John.2022.pdf
ER  -