000009744 001__ 9744
000009744 005__ 20240124114329.0
000009744 0247_ $$2DOI$$a10.6083/3r074v67t
000009744 037__ $$aETD
000009744 245__ $$aMechanistic correlates of selective breeding for methamphetamine intake
000009744 260__ $$bOregon Health and Science University
000009744 269__ $$a2022
000009744 336__ $$aDissertation
000009744 502__ $$bPh.D.
000009744 520__ $$aWhile any number of social, psychological, and economic factors contribute to methamphetamine (MA) addiction risk, numerous biological variables have also been identified.The broad goals of this dissertation are to explore the mechanistic correlates of selective breeding for MA intake. The intent of the first aim was to further characterize the receptor encoded by Taar1m1J. Previous work found that this receptor does not produce a cAMP response in the presence of agonist. I build on this by demonstrating the TAAR1 encoded by Taar1m1J binds ligand with drastically reduce affinity. Thus, responses to TAAR1 agonists, such as MA, in these mice are more likely due to impaired ligand binding.  The second aim focused on the hypothermic effects of addictive drugs in the MADR lines.
000009744 542__ $$fIn copyright - single owner
000009744 650__ $$aMethamphetamine$$022135
000009744 650__ $$aGenetic Linkage$$021524
000009744 650__ $$aSelective Breeding$$011277
000009744 6531_ $$adrug addiction
000009744 6531_ $$amu opioid receptor
000009744 6531_ $$atrace amine receptor 1
000009744 691__ $$aSchool of Medicine$$041369
000009744 692__ $$aDepartment of Behavioral Neuroscience$$041394
000009744 7001_ $$aMootz, John R. K.
000009744 8564_ $$9bb5d3bdb-662c-4b37-a0fe-88daff528a1b$$s2790787$$uhttps://digitalcollections.ohsu.edu/record/9744/files/Mootz.John.2022.pdf
000009744 905__ $$a/rest/prod/3r/07/4v/67/3r074v67t
000009744 909CO $$ooai:digitalcollections.ohsu.edu:9744$$pstudent-work
000009744 980__ $$aTheses and Dissertations