000009746 001__ 9746 000009746 005__ 20231129124952.0 000009746 0247_ $$2DOI$$a10.6083/gf06g3342 000009746 037__ $$aETD 000009746 245__ $$aQuantifying the single-cell spatial composition of the breast tumor microenvironment 000009746 260__ $$bOregon Health and Science University 000009746 269__ $$a2022 000009746 336__ $$aThesis 000009746 502__ $$bPh.D. 000009746 520__ $$aThe breast tumor microenvironment is a complex ecosystem of epithelial, immune, endothelial, fibroblast and adipose cells. Cellular phenotypes and spatial localizations within the microenvironment are linked to patient prognosis and response to therapy. Our CyCIF protocol, image analysis tools and atlases of breast cancer tissues all contribute to deepening our understanding of the tumor microenvironment in order to improve patient stratification and inform therapeutic strategies. 000009746 650__ $$aMass Spectrometry$$026224 000009746 650__ $$aBreast Neoplasms$$015809 000009746 650__ $$aImage Cytometry$$031308 000009746 650__ $$a Tumor Microenvironment$$039473 000009746 691__ $$aSchool of Medicine$$041369 000009746 692__ $$aDepartment of Biomedical Engineering$$041397 000009746 7001_ $$aJennifer, Eng, 000009746 8564_ $$99f521a78-4ad9-4faa-ad89-e01e0cfb3c33$$s16215168$$uhttps://digitalcollections.ohsu.edu/record/9746/files/Eng.Jenny.2022.pdf 000009746 905__ $$a/rest/prod/gf/06/g3/34/gf06g3342 000009746 909CO $$ooai:digitalcollections.ohsu.edu:9746$$pstudent-work 000009746 980__ $$aTheses and Dissertations