@article{ETD, school = {Ph.D.}, author = {Stonebarger, Gail}, url = {http://digitalcollections.ohsu.edu/record/9751}, title = {A clinically driven characterization of pathological and non-pathological brain aging in the Rhesus Macaque model: impact of caloric restriction}, publisher = {Oregon Health and Science University}, abstract = {This dissertation focuses on brain aging and neurodegeneration, specifically in the context of healthy brain aging versus Alzheimer's disease (AD). To study these processes, a translational model of human aging is necessitated; therefore, this dissertation will focus on the rhesus macaque's utility in modeling clinically normative and pathological brain aging. Protein-level consequences of central nervous system (CNS) aging in monkeys will be experimentally explored and discussed in comparison to concomitant clinical phenotypes.}, number = {ETD}, doi = {https://doi.org/10.6083/zs25x9220}, recid = {9751}, address = {2022}, }