000009751 001__ 9751
000009751 005__ 20231129124949.0
000009751 0247_ $$2DOI$$a10.6083/zs25x9220
000009751 037__ $$aETD
000009751 245__ $$aA clinically driven characterization of pathological and non-pathological brain aging in the Rhesus Macaque model: impact of caloric restriction
000009751 260__ $$bOregon Health and Science University
000009751 269__ $$a2022
000009751 336__ $$aDissertation
000009751 502__ $$bPh.D.
000009751 520__ $$aThis dissertation focuses on brain aging and neurodegeneration, specifically in the context of healthy brain aging versus Alzheimer's disease (AD). To study these processes, a translational model of human aging is necessitated; therefore, this dissertation will focus on the rhesus macaque's utility in modeling clinically normative and pathological brain aging. Protein-level consequences of central nervous system (CNS) aging in monkeys will be experimentally explored and discussed in comparison to concomitant clinical phenotypes.
000009751 542__ $$fIn copyright - single owner
000009751 650__ $$aAmyloid beta-Peptides$$028982
000009751 650__ $$aMacaca mulatta$$021724
000009751 650__ $$aAlzheimer Disease$$014513
000009751 650__ $$aCaloric Restriction$$033930
000009751 650__ $$aAging$$014358
000009751 650__ $$aBiomarkers$$028395
000009751 691__ $$aSchool of Medicine$$041369
000009751 692__ $$aDepartment of Behavioral Neuroscience$$041394
000009751 7001_ $$aStonebarger, Gail
000009751 8564_ $$94323e231-5974-45a2-bf4d-489b528362f1$$s20760091$$uhttps://digitalcollections.ohsu.edu/record/9751/files/Stonebarger.Gail.2022.pdf
000009751 905__ $$a/rest/prod/zs/25/x9/22/zs25x9220
000009751 909CO $$ooai:digitalcollections.ohsu.edu:9751$$pstudent-work
000009751 980__ $$aTheses and Dissertations