TY  - GEN
N2  - Malaria is a mosquito-borne parasitic disease that has deeply impacted the human population throughout recorded history. The disease burden of malaria has gradually declined over the last few decades due to continuing global efforts towards its eradication. In the past two years however, this trend has unfortunately stalled and reversed as healthcare resources are diverted to address the global COVID-19 pandemic. Though the GSK-developed RTS-S vaccine was recently approved by the WHO for malaria prevention, this tool will not be sufficient on its own to eradicate malaria, particularly as antimalarial drug resistance is rapidly spreading. The research described in this dissertation applies to two chemical scaffolds with excellent potential as antimalarial drugs, the aminoguanidines and the endochin-like quinolones.
DO  - 10.6083/6682x458m
DO  - DOI
AB  - Malaria is a mosquito-borne parasitic disease that has deeply impacted the human population throughout recorded history. The disease burden of malaria has gradually declined over the last few decades due to continuing global efforts towards its eradication. In the past two years however, this trend has unfortunately stalled and reversed as healthcare resources are diverted to address the global COVID-19 pandemic. Though the GSK-developed RTS-S vaccine was recently approved by the WHO for malaria prevention, this tool will not be sufficient on its own to eradicate malaria, particularly as antimalarial drug resistance is rapidly spreading. The research described in this dissertation applies to two chemical scaffolds with excellent potential as antimalarial drugs, the aminoguanidines and the endochin-like quinolones.
T1  - Antimalarial activity of aminoguanidines
DA  - 2022
AU  - Krollenbrock, Alina R.
L1  - https://digitalcollections.ohsu.edu/record/9753/files/Krollenbrock.Alina.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9753
L4  - https://digitalcollections.ohsu.edu/record/9753/files/Krollenbrock.Alina.2022.pdf
KW  - Drug Discovery
KW  - Robenidine
KW  - Malaria
KW  - Antimalarials
KW  - Quinolones
KW  - pimagedine
KW  - medicinal chemistry
TI  - Antimalarial activity of aminoguanidines
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9753/files/Krollenbrock.Alina.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9753/files/Krollenbrock.Alina.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9753/files/Krollenbrock.Alina.2022.pdf
ER  -