000009753 001__ 9753
000009753 005__ 20240124114330.0
000009753 0247_ $$2DOI$$a10.6083/6682x458m
000009753 037__ $$aETD
000009753 245__ $$aAntimalarial activity of aminoguanidines
000009753 260__ $$bOregon Health and Science University
000009753 269__ $$a2022
000009753 336__ $$aDissertation
000009753 502__ $$bPh.D.
000009753 520__ $$aMalaria is a mosquito-borne parasitic disease that has deeply impacted the human population throughout recorded history. The disease burden of malaria has gradually declined over the last few decades due to continuing global efforts towards its eradication. In the past two years however, this trend has unfortunately stalled and reversed as healthcare resources are diverted to address the global COVID-19 pandemic. Though the GSK-developed RTS-S vaccine was recently approved by the WHO for malaria prevention, this tool will not be sufficient on its own to eradicate malaria, particularly as antimalarial drug resistance is rapidly spreading. The research described in this dissertation applies to two chemical scaffolds with excellent potential as antimalarial drugs, the aminoguanidines and the endochin-like quinolones.
000009753 542__ $$fIn copyright - single owner
000009753 650__ $$aDrug Discovery$$038473
000009753 650__ $$aRobenidine$$025583
000009753 650__ $$aMalaria$$021755
000009753 650__ $$aAntimalarials$$014903
000009753 650__ $$aQuinolones$$028355
000009753 6531_ $$apimagedine
000009753 6531_ $$amedicinal chemistry
000009753 691__ $$aSchool of Medicine$$041369
000009753 692__ $$aDepartment of Physiology and Pharmacology$$041442
000009753 7001_ $$aKrollenbrock, Alina R.
000009753 8564_ $$90fa783d4-1604-42a3-a59f-e548c1506189$$s7692136$$uhttps://digitalcollections.ohsu.edu/record/9753/files/Krollenbrock.Alina.2022.pdf
000009753 905__ $$a/rest/prod/66/82/x4/58/6682x458m
000009753 909CO $$ooai:digitalcollections.ohsu.edu:9753$$pstudent-work
000009753 980__ $$aTheses and Dissertations