TY  - GEN
N2  - Atherosclerosis is the leading cause of cardiovascular disease, accounting for nearly 30% of deaths in the United States. Patients with late-stage atherosclerosis suffer from life-threatening complications, such as myocardial infarctions, ischemic strokes, aneurysms, and multi-organ failure. Many current treatment options, including anti-platelet and anti-coagulant therapies, although moderately effective at alleviating or preventing thrombotic events of atherosclerosis, carry a risk for bleeding and hemorrhagic complications. Thus, there remains a need to further understand the molecular basis of hemostasis and thrombosis in order develop safer and more effective therapies. The goal of this thesis is to investigate mechanisms in which tyrosine kinase inhibitors reduce thrombotic events, while maintaining hemostasis processes in atherosclerosis, to guide therapeutic interventions for future patients.
DO  - 10.6083/nz806044h
DO  - DOI
AB  - Atherosclerosis is the leading cause of cardiovascular disease, accounting for nearly 30% of deaths in the United States. Patients with late-stage atherosclerosis suffer from life-threatening complications, such as myocardial infarctions, ischemic strokes, aneurysms, and multi-organ failure. Many current treatment options, including anti-platelet and anti-coagulant therapies, although moderately effective at alleviating or preventing thrombotic events of atherosclerosis, carry a risk for bleeding and hemorrhagic complications. Thus, there remains a need to further understand the molecular basis of hemostasis and thrombosis in order develop safer and more effective therapies. The goal of this thesis is to investigate mechanisms in which tyrosine kinase inhibitors reduce thrombotic events, while maintaining hemostasis processes in atherosclerosis, to guide therapeutic interventions for future patients.
T1  - Role of platelet tyrosine kinases in atherosclerosis
DA  - 2022
AU  - Zheng, Tony J.
L1  - https://digitalcollections.ohsu.edu/record/9755/files/Zheng.Tony.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9755
L4  - https://digitalcollections.ohsu.edu/record/9755/files/Zheng.Tony.2022.pdf
KW  - Blood Platelets
KW  - Atherosclerosis
KW  - Protein-Tyrosine Kinases
KW  - oxldl
KW  - ibrutinib
TI  - Role of platelet tyrosine kinases in atherosclerosis
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9755/files/Zheng.Tony.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9755/files/Zheng.Tony.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9755/files/Zheng.Tony.2022.pdf
ER  -