TY  - GEN
N2  - The majority of pharmaceutical drugs on the market target G protein coupled receptor (GPCRs); however, GPCR signaling and regulation adapt in response to environmental stimuli. One GPCR gaining attention due to the increasing legalization of cannabis is the cannabinoid 1 receptor (CB1R). Cannabis legalization is leading to increased use to treat pain and other ailments, including pain caused by inflammation. Studies presented throughout this dissertation investigate adaptations in synaptic CB1R suppression of GABA release after persistent inflammation induced by Complete Freund?s Adjuvant (CFA).
DO  - 10.6083/8336h2599
DO  - DOI
AB  - The majority of pharmaceutical drugs on the market target G protein coupled receptor (GPCRs); however, GPCR signaling and regulation adapt in response to environmental stimuli. One GPCR gaining attention due to the increasing legalization of cannabis is the cannabinoid 1 receptor (CB1R). Cannabis legalization is leading to increased use to treat pain and other ailments, including pain caused by inflammation. Studies presented throughout this dissertation investigate adaptations in synaptic CB1R suppression of GABA release after persistent inflammation induced by Complete Freund?s Adjuvant (CFA).
T1  - Persistent inflammation desensitizes the presynaptic cannabinoid CB1 receptor
DA  - 2022
AU  - Bouchet, Courtney A.
L1  - https://digitalcollections.ohsu.edu/record/9759/files/Bouchet.Courtney.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9759
L4  - https://digitalcollections.ohsu.edu/record/9759/files/Bouchet.Courtney.2022.pdf
KW  - Cannabinoids
KW  - Corticosterone
KW  - Periaqueductal Gray
KW  - Inflammation
KW  - g-protein-coupled receptors
TI  - Persistent inflammation desensitizes the presynaptic cannabinoid CB1 receptor
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9759/files/Bouchet.Courtney.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9759/files/Bouchet.Courtney.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9759/files/Bouchet.Courtney.2022.pdf
ER  -