000009759 001__ 9759
000009759 005__ 20240124114330.0
000009759 0247_ $$2DOI$$a10.6083/8336h2599
000009759 037__ $$aETD
000009759 245__ $$aPersistent inflammation desensitizes the presynaptic cannabinoid CB1 receptor
000009759 260__ $$bOregon Health and Science University
000009759 269__ $$a2022
000009759 336__ $$aDissertation
000009759 502__ $$bPh.D.
000009759 520__ $$aThe majority of pharmaceutical drugs on the market target G protein coupled receptor (GPCRs); however, GPCR signaling and regulation adapt in response to environmental stimuli. One GPCR gaining attention due to the increasing legalization of cannabis is the cannabinoid 1 receptor (CB1R). Cannabis legalization is leading to increased use to treat pain and other ailments, including pain caused by inflammation. Studies presented throughout this dissertation investigate adaptations in synaptic CB1R suppression of GABA release after persistent inflammation induced by Complete Freund?s Adjuvant (CFA).
000009759 542__ $$fIn copyright - single owner
000009759 650__ $$aCannabinoids$$016024
000009759 650__ $$aCorticosterone$$017130
000009759 650__ $$aPeriaqueductal Gray$$023800
000009759 650__ $$aInflammation$$020800
000009759 6531_ $$ag-protein-coupled receptors
000009759 691__ $$aSchool of Medicine$$041369
000009759 692__ $$aVollum Institute$$041509
000009759 7001_ $$aBouchet, Courtney A.
000009759 8564_ $$9c7a0926a-52ce-4ea7-bf8f-e5ee197d6291$$s3189090$$uhttps://digitalcollections.ohsu.edu/record/9759/files/Bouchet.Courtney.2022.pdf
000009759 905__ $$a/rest/prod/83/36/h2/59/8336h2599
000009759 909CO $$ooai:digitalcollections.ohsu.edu:9759$$pstudent-work
000009759 980__ $$aTheses and Dissertations