000000976 001__ 976
000000976 005__ 20260120144841.0
000000976 0247_ $$2DOI$$a10.6083/M4H41PGS
000000976 037__ $$aETD
000000976 245__ $$aSelection and behavior of inflationary CD8 T-cell populations during mirine cytomegalovirus infection
000000976 260__ $$bOregon Health and Science University
000000976 269__ $$a2013
000000976 336__ $$aDissertation
000000976 502__ $$bPh.D.
000000976 502__ $$gMolecular Microbiology & Immunology (sunsetting)
000000976 520__ $$aCytomegalovirus (CMV) establishes lifelong infection and drives “memory inflation,” a persistent CD8 T-cell response with effector characteristics. This property makes CMV an attractive vaccine vector, yet the mechanisms determining which viral epitopes inflate remain unclear. Using murine CMV encoding the SIINFEKL epitope, we show that epitope placement within the viral genome influences immunodominance, with SIINFEKL at the IE2 locus driving strong inflation. Coinfection experiments reveal that antigen availability at the level of antigen-presenting cells shapes inflationary selection. Additionally, intravenous peptide administration boosted both inflationary and central memory responses, suggesting a strategy for enhancing CMV-based vaccines and challenging assumptions about peptide-induced tolerance.
000000976 540__ $$fCC BY
000000976 542__ $$fIn copyright - single owner
000000976 650__ $$aMuromegalovirus$$030544
000000976 650__ $$aImmunologic Memory$$020713
000000976 650__ $$aCD8-Positive T-Lymphocytes$$030782
000000976 650__ $$aCytomegalovirus$$017352
000000976 650__ $$aCytomegalovirus Infections$$017351
000000976 6531_ $$aimmunological tolerance
000000976 691__ $$aSchool of Medicine$$041369
000000976 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000000976 7001_ $$aFarrington, Lila$$uOregon Health and Science University$$041354
000000976 7201_ $$aHill, Ann$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000976 8564_ $$9e8f4b07d-9ce4-4670-82bf-bc022962674d$$s3671898$$uhttps://digitalcollections.ohsu.edu/record/976/files/979_etd.pdf$$ePublic$$20be752ad5bced63075a33108b839219a$$31
000000976 905__ $$a/rest/prod/1c/18/df/81/1c18df81z
000000976 909CO $$ooai:digitalcollections.ohsu.edu:976$$pstudent-work
000000976 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000976 980__ $$aTheses and Dissertations