@article{ETD,
      school = {Ph.D.},
      author = {McCarthy, Grace A.},
      url = {http://digitalcollections.ohsu.edu/record/9761},
      title = {Elucidating the impact of tumor intrinsic HuR on the PDAC  microenvironment},
      publisher = {Oregon Health and Science University},
      abstract = {The overwhelming majority (~90%) of patients with  pancreatic ductal adenocarcinoma (PDAC) will be treated  with systemic standard-of-care chemotherapeutic regimens at  some point during their care. These treatments have limited  benefits for patients, in addition to causing adverse side  effects. One of the contributing factors to poor treatment  response is PDAC?s characteristically dense stroma and  heterogeneous tumor microenvironment. For instance,  pancreatic stellate cells (PSCs) and cancer associated  fibroblasts (CAFs) in pancreatic tumors promote fibrosis,  which is associated with poor prognosis and resistance to  therapy. 

Herein, this thesis describes a novel function  of tumor intrinsic HuR in the PDAC tumor microenvironment  and proposes a method of direct and specific inhibition of  HuR in PDAC tumors. In doing so, we aimed to address the  need for improved treatments for PDAC, by both manipulating  the tumor microenvironment to improve therapeutic efficacy  and optimizing a novel, targeted delivery method for  payloads.},
      number = {ETD},
      doi = {https://doi.org/10.6083/xd07gt34x},
      recid = {9761},
      address = {2022},
}