TY  - GEN
N2  - The overwhelming majority (~90%) of patients with pancreatic ductal adenocarcinoma (PDAC) will be treated with systemic standard-of-care chemotherapeutic regimens at some point during their care. These treatments have limited benefits for patients, in addition to causing adverse side effects. One of the contributing factors to poor treatment response is PDAC?s characteristically dense stroma and heterogeneous tumor microenvironment. For instance, pancreatic stellate cells (PSCs) and cancer associated fibroblasts (CAFs) in pancreatic tumors promote fibrosis, which is associated with poor prognosis and resistance to therapy. 

Herein, this thesis describes a novel function of tumor intrinsic HuR in the PDAC tumor microenvironment and proposes a method of direct and specific inhibition of HuR in PDAC tumors. In doing so, we aimed to address the need for improved treatments for PDAC, by both manipulating the tumor microenvironment to improve therapeutic efficacy and optimizing a novel, targeted delivery method for payloads.
DO  - 10.6083/xd07gt34x
DO  - DOI
AB  - The overwhelming majority (~90%) of patients with pancreatic ductal adenocarcinoma (PDAC) will be treated with systemic standard-of-care chemotherapeutic regimens at some point during their care. These treatments have limited benefits for patients, in addition to causing adverse side effects. One of the contributing factors to poor treatment response is PDAC?s characteristically dense stroma and heterogeneous tumor microenvironment. For instance, pancreatic stellate cells (PSCs) and cancer associated fibroblasts (CAFs) in pancreatic tumors promote fibrosis, which is associated with poor prognosis and resistance to therapy. 

Herein, this thesis describes a novel function of tumor intrinsic HuR in the PDAC tumor microenvironment and proposes a method of direct and specific inhibition of HuR in PDAC tumors. In doing so, we aimed to address the need for improved treatments for PDAC, by both manipulating the tumor microenvironment to improve therapeutic efficacy and optimizing a novel, targeted delivery method for payloads.
T1  - Elucidating the impact of tumor intrinsic HuR on the PDAC microenvironment
DA  - 2022
AU  - McCarthy, Grace A.
L1  - https://digitalcollections.ohsu.edu/record/9761/files/McCarthy.Grace.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9761
L4  - https://digitalcollections.ohsu.edu/record/9761/files/McCarthy.Grace.2022.pdf
KW  - RNA-Binding Proteins
KW  - Stromal Cells
KW  - Cell Communication
KW  - pancreatic ductal carcinoma
KW  - nanocarrier
TI  - Elucidating the impact of tumor intrinsic HuR on the PDAC microenvironment
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9761/files/McCarthy.Grace.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9761/files/McCarthy.Grace.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9761/files/McCarthy.Grace.2022.pdf
ER  -