000009839 001__ 9839
000009839 005__ 20240124114330.0
000009839 0247_ $$2DOI$$a10.6083/1544bp783
000009839 037__ $$aETD
000009839 245__ $$aMaternal western style diet and associated metabolic changes influence social outcomes and neurodevelopment in Japanese Macaques
000009839 260__ $$bOregon Health and Science University
000009839 269__ $$a2022
000009839 336__ $$aDissertation
000009839 520__ $$aThe CDC reports that almost 30% of women in the US were diagnosed with maternal obesity in 2019. Maternal obesity is associated with increased risk of early onset neurodevelopmental disorders such as Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and mood disorders in children. Although these trends may be driven in part by the improved accuracy regarding our characterization of behavioral phenotypes associated with a neurodevelopmental disorders, there is still much to be learned about their developmental origins. Increasing evidence from epidemiological and preclinical animal models suggest that maternal overnutrition of Western-style diet alters fetal neurodevelopment, and impairs socio-emotional function in offspring. This dissertation explores this hypothesis further and investigates the impact of perinatal maternal WSD (mWSD) exposure within the translatable preclinical macaque (Macaca fuscata) model.
000009839 542__ $$fIn copyright - single owner
000009839 650__ $$aAttention Deficit Disorder with Hyperactivity$$015204
000009839 650__ $$aAutism Spectrum Disorder$$011199
000009839 650__ $$aPregnancy$$024523
000009839 650__ $$aBrain$$015788
000009839 650__ $$aSocial Behavior$$026095
000009839 6531_ $$aexperimental animal models
000009839 691__ $$aSchool of Medicine$$041369
000009839 692__ $$aDepartment of Behavioral Neuroscience$$041394
000009839 7001_ $$aMitchell, Thomas "AJ"
000009839 8564_ $$935e580eb-8ae2-46a6-8402-6dbb3c078d73$$s4763059$$uhttps://digitalcollections.ohsu.edu/record/9839/files/Mitchell.AJ.2022.pdf
000009839 905__ $$a/rest/prod/15/44/bp/78/1544bp783
000009839 909CO $$ooai:digitalcollections.ohsu.edu:9839$$pstudent-work
000009839 980__ $$aTheses and Dissertations