000009951 001__ 9951
000009951 005__ 20240124114331.0
000009951 0247_ $$2DOI$$a10.6083/pk02cb445
000009951 037__ $$aETD
000009951 245__ $$aGlial support of axon maintenance requires the TGFβ receptor babo
000009951 260__ $$bOregon Health and Science University
000009951 269__ $$a2022
000009951 336__ $$aDissertation
000009951 502__ $$bPh.D.
000009951 520__ $$aAxons can represent the majority of a neuron's volume and are energetically demanding. Specialized glia ensheathe axons to insulate them and are believed to support axon function and maintenance throughout life. The morphology of axon-associated glia is complex and requires massive growth during development. Glial cells must search for and identify the proper axonal targets, sort them from other axons, and ultimately fully ensheathe them. Despite their importance, little is known about how glia ensheathe axons, what glia do to support neurons, and even less is known about how those functions are regulated throughout the life of an organism. Understanding the mechanisms involved in coordinating this complex process is critical as improper ensheathment can impede the ability of glia to support axons. Human diseases such as multiple sclerosis (MS) or Charcot-Marie-Tooth disease (CMT) are characterized by loss of glia that ensheathe axons resulting in functional impairment and progressive degeneration of neurons. In this dissertation I sought to provide new insights into how glia support neurons and in doing so, identified several genes encoding secreted and transmembrane proteins that are required in glia for long-term axon survival in vivo.
000009951 542__ $$fIn copyright - single owner
000009951 650__ $$aWallerian Degeneration$$027922
000009951 650__ $$aDrosophila$$018058
000009951 650__ $$aNeuroglia$$022841
000009951 650__ $$aAxons$$015276
000009951 6531_ $$atgfbeta
000009951 6531_ $$ababo protein
000009951 691__ $$aSchool of Medicine$$041369
000009951 692__ $$aVollum Institute$$041509
000009951 7001_ $$aLassetter, Alexandria
000009951 8564_ $$93f50114e-cc05-4693-9d4f-72942b998734$$s5118004$$uhttps://digitalcollections.ohsu.edu/record/9951/files/Lassetter.Alexandria.2022.pdf
000009951 905__ $$a/rest/prod/pk/02/cb/44/pk02cb445
000009951 909CO $$ooai:digitalcollections.ohsu.edu:9951$$pstudent-work
000009951 980__ $$aTheses and Dissertations