000009952 001__ 9952
000009952 005__ 20231129124952.0
000009952 0247_ $$2DOI$$a10.6083/70795846b
000009952 037__ $$aETD
000009952 245__ $$aNeural and molecular mechanisms of pathogen avoidance in caenorhabditis elegans
000009952 260__ $$bOregon Health and Science University
000009952 269__ $$a2022
000009952 336__ $$aDissertation
000009952 502__ $$bPh.D.
000009952 520__ $$aUpon exposure to harmful microorganisms, hosts engage in protective molecular and behavioral immune responses, both of which are ultimately regulated by the nervous system. In this dissertation, the use of Caenorhabditis elegans bacterial infection models have allowed for many insights into the mechanisms of these immune responses, including some of the chemosensory neurons involved in the reduction of pathogen exposure via altering of behavior, or pathogen avoidance. However, key questions remain unanswered: how does intestinal infection lead to pathogen avoidance? What does the neural circuitry between chemosensory neurons that sense pathogenic bacterial cues and the motor neurons responsible for avoidance-associated locomotion look like? This dissertation attempts to answer these questions by using the genetic and computational tools available in C. elegans to probe the molecular pathways and neural circuits underlying pathogen avoidance.
000009952 542__ $$fIn copyright - single owner
000009952 650__ $$aCaenorhabditis elegans$$029747
000009952 650__ $$aTRPM Cation Channels$$036305
000009952 650__ $$aAvoidance Learning$$015269
000009952 650__ $$aMotor Neurons$$022454
000009952 691__ $$aSchool of Medicine$$041369
000009952 692__ $$aVollum Institute$$041509
000009952 7001_ $$aFilipowicz, Adam R.
000009952 8564_ $$9462f2a1d-891e-4a2c-a286-45873757e962$$s4814088$$uhttps://digitalcollections.ohsu.edu/record/9952/files/Filipowicz.Adam.2022.pdf
000009952 905__ $$a/rest/prod/70/79/58/46/70795846b
000009952 909CO $$ooai:digitalcollections.ohsu.edu:9952$$pstudent-work
000009952 980__ $$aTheses and Dissertations