@article{ETD,
      school = {Ph.D.},
      author = {Lin, Hsin-Yun},
      url = {http://digitalcollections.ohsu.edu/record/9954},
      title = {Identification of TLK/ASF1 as a novel pathway for  mediating IL-1B-driven acute myeloid leukemia},
      publisher = {Oregon Health and Science University},
      abstract = {Genetic heterogeneity makes clinical interventions  challenging for patients with acute myeloid leukemia (AML).  Identifying and targeting common microenvironment-driven  pathways should allow the development of effective  therapies across AML genetic subtypes. Our laboratory has  previously shown that the AML microenvironment is rich in  proinflammatory cytokine interleukin-1B (IL-1B) and  promotes the growth of AML progenitors. To elucidate the  molecular underpinnings of IL-1B-driven AML progression,  transcriptome analysis was performed and identified that  ASF1B (anti-silencing function-1B) is one of the most  differentially expressed genes in AML compared to healthy  progenitors. This dissertation focuses on how ASF1B, and  its regulator tousled-like kinase 2 (TLK2) contribute to  AML cell growth and IL-1B-driven AML progression.},
      number = {ETD},
      doi = {https://doi.org/10.6083/4t64gn939},
      recid = {9954},
      address = {2022},
}