TY  - GEN
N2  - Genetic heterogeneity makes clinical interventions challenging for patients with acute myeloid leukemia (AML). Identifying and targeting common microenvironment-driven pathways should allow the development of effective therapies across AML genetic subtypes. Our laboratory has previously shown that the AML microenvironment is rich in proinflammatory cytokine interleukin-1B (IL-1B) and promotes the growth of AML progenitors. To elucidate the molecular underpinnings of IL-1B-driven AML progression, transcriptome analysis was performed and identified that ASF1B (anti-silencing function-1B) is one of the most differentially expressed genes in AML compared to healthy progenitors. This dissertation focuses on how ASF1B, and its regulator tousled-like kinase 2 (TLK2) contribute to AML cell growth and IL-1B-driven AML progression.
DO  - 10.6083/4t64gn939
DO  - DOI
AB  - Genetic heterogeneity makes clinical interventions challenging for patients with acute myeloid leukemia (AML). Identifying and targeting common microenvironment-driven pathways should allow the development of effective therapies across AML genetic subtypes. Our laboratory has previously shown that the AML microenvironment is rich in proinflammatory cytokine interleukin-1B (IL-1B) and promotes the growth of AML progenitors. To elucidate the molecular underpinnings of IL-1B-driven AML progression, transcriptome analysis was performed and identified that ASF1B (anti-silencing function-1B) is one of the most differentially expressed genes in AML compared to healthy progenitors. This dissertation focuses on how ASF1B, and its regulator tousled-like kinase 2 (TLK2) contribute to AML cell growth and IL-1B-driven AML progression.
T1  - Identification of TLK/ASF1 as a novel pathway for mediating IL-1B-driven acute myeloid leukemia
DA  - 2022
AU  - Lin, Hsin-Yun
L1  - https://digitalcollections.ohsu.edu/record/9954/files/Lin.HsinYun.2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9954
L4  - https://digitalcollections.ohsu.edu/record/9954/files/Lin.HsinYun.2022.pdf
KW  - Interleukin-1
KW  - DNA Damage
KW  - Histone Chaperones
KW  - tousled like kinase 2
KW  - mouse
KW  - acute myeloid leukemia
KW  - asf1b protein
TI  - Identification of TLK/ASF1 as a novel pathway for mediating IL-1B-driven acute myeloid leukemia
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9954/files/Lin.HsinYun.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9954/files/Lin.HsinYun.2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9954/files/Lin.HsinYun.2022.pdf
ER  -