Dissertation Lin, Hsin-Yun Identification of TLK/ASF1 as a novel pathway for mediating IL-1B-driven acute myeloid leukemia 10.6083/4t64gn939 Genetic heterogeneity makes clinical interventions challenging for patients with acute myeloid leukemia (AML). Identifying and targeting common microenvironment-driven pathways should allow the development of effective therapies across AML genetic subtypes. Our laboratory has previously shown that the AML microenvironment is rich in proinflammatory cytokine interleukin-1B (IL-1B) and promotes the growth of AML progenitors. To elucidate the molecular underpinnings of IL-1B-driven AML progression, transcriptome analysis was performed and identified that ASF1B (anti-silencing function-1B) is one of the most differentially expressed genes in AML compared to healthy progenitors. This dissertation focuses on how ASF1B, and its regulator tousled-like kinase 2 (TLK2) contribute to AML cell growth and IL-1B-driven AML progression. mouse; asf1b protein; tousled like kinase 2; Interleukin-1; DNA Damage; Histone Chaperones; Leukemia, Myeloid, Acute; Oregon Health and Science University

https://digitalcollections.ohsu.edu/record/9954/files/Lin.HsinYun.2022.pdf;