000009958 001__ 9958
000009958 005__ 20231129124952.0
000009958 0247_ $$2DOI$$a10.6083/5999n428r
000009958 037__ $$aETD
000009958 245__ $$aInvestigating the role of glutathione in Drosophila lifespan and neuronal health
000009958 260__ $$bOregon Health and Science University
000009958 269__ $$a2022
000009958 336__ $$aThesis
000009958 502__ $$bM.S.
000009958 520__ $$aThe greatest risk factor for developing Parkinson's disease is aging, and the accumulation of reactive oxygen species is thought to play a significant role in the aging process. Glutathione is a universal antioxidant in animals and plants that helps maintain redox homeostasis within cells, preventing or delaying excessive buildup of reactive oxygen species that may damage or destroy the cell. The work presented in this thesis adds to our understanding of how glutathione affects the aging process and its therapeutic potential in aging-related neurodegenerative diseases like Parkinson's disease.
000009958 650__ $$aAntioxidants$$014915
000009958 650__ $$aLongevity$$021616
000009958 650__ $$aAging$$014358
000009958 650__ $$aNeurosciences$$022870
000009958 650__ $$aDrosophila melanogaster$$018059
000009958 650__ $$aOxidative Stress$$030758
000009958 691__ $$aSchool of Medicine$$041369
000009958 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000009958 7001_ $$aColeman,  Colin
000009958 8564_ $$947fe7cbf-a7c7-473c-bae9-d956e96c524c$$s1653868$$uhttps://digitalcollections.ohsu.edu/record/9958/files/Coleman.Colin.2022.pdf
000009958 905__ $$a/rest/prod/59/99/n4/28/5999n428r
000009958 909CO $$ooai:digitalcollections.ohsu.edu:9958$$pstudent-work
000009958 980__ $$aTheses and Dissertations