000009963 001__ 9963
000009963 005__ 20240124114331.0
000009963 0247_ $$2DOI$$a10.6083/tq57nr911
000009963 037__ $$aETD
000009963 245__ $$aBlood biomarker signal amplification technologies for pancreatic cancer early detection
000009963 260__ $$bOregon Health and Science University
000009963 269__ $$a2022
000009963 336__ $$aDissertation
000009963 502__ $$bPh.D.
000009963 520__ $$aPancreatic ductal adenocarcinoma (PDAC) has the lowest 5-year survival rate of all major malignancies (11%). In particular, late-stage malignancies have only a 5% 5-year survival rate, whereas early-stage malignancies have a 4 times higher 5-year survival rate. Unfortunately, only 20% of malignancies are caught in early stages. Liquid biopsy has emerged as a possible solution for cancer screening since it allows less invasive, un-biased and serial analysis of cancer biomarkers from the same individual. The most notorious limitation of liquid biopsy is the signal-to-noise ratio (SNR) of cancer-related biomarkers since cancer cells make up a tiny fraction of the total number of cells in the body. To improve patient outcomes through early cancer screening, innovative liquid biopsy PDAC-specific biomarkers with enhanced SNR must be found and validated. The following set of studies combines engineering, biology, biotechnology, and nanotechnology to produce innovative PDAC screening tools with enhanced SNR compared to traditional technologies.
000009963 542__ $$fIn copyright - single owner
000009963 650__ $$aLiquid Biopsy$$012229
000009963 650__ $$aPancreatic Neoplasms$$023517
000009963 650__ $$aEarly Detection of Cancer$$038151
000009963 6531_ $$atumor biomarkers
000009963 691__ $$aSchool of Medicine$$041369
000009963 692__ $$aDepartment of Biomedical Engineering$$041397
000009963 7001_ $$aMontoya Mira, Jose L.
000009963 8564_ $$95b0b555b-8bd2-4736-b2f0-cab29e0a8bbd$$s14625792$$uhttps://digitalcollections.ohsu.edu/record/9963/files/Mira.Jose.2022.pdf
000009963 905__ $$a/rest/prod/tq/57/nr/91/tq57nr911
000009963 909CO $$ooai:digitalcollections.ohsu.edu:9963$$pstudent-work
000009963 980__ $$aTheses and Dissertations