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000009965 0247_ $$2DOI$$a10.6083/k930bx65n
000009965 037__ $$aETD
000009965 245__ $$aRegulation of cytoskeletal dynamics promotes proper collective cell migration
000009965 260__ $$bOregon Health and Science University
000009965 269__ $$a2022
000009965 336__ $$aDissertation
000009965 502__ $$bPh.D.
000009965 520__ $$aDuring development, cells must migrate from their origin to their final destination, a process that is dependent on the actin cytoskeleton. Cells can migrate independently or cohesively as a unit, in a process known as collective cell migration. In migrating cells, the actin cytoskeleton facilitates migration through the extension of actin-based protrusions, promoting adherence to the extracellular environment, and the retraction of trailing portions of cells. The regulation of these actin-based cellular mechanisms has been heavily studied in populations of individually migrating cells, mostly in in vitro contexts. However, how these processes are regulated and coordinated during collective cell migration in vivo remains largely unknown.
000009965 542__ $$fIn copyright - single owner
000009965 650__ $$aCell Movement$$016289
000009965 650__ $$aConstriction$$017037
000009965 650__ $$aZebrafish$$028076
000009965 650__ $$aDevelopmental Biology$$028463
000009965 691__ $$aSchool of Medicine$$041369
000009965 692__ $$aVollum Institute$$041509
000009965 7001_ $$aOlson, Hannah M.
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000009965 909CO $$ooai:digitalcollections.ohsu.edu:9965$$pstudent-work
000009965 980__ $$aTheses and Dissertations