000009974 001__ 9974
000009974 005__ 20240124114332.0
000009974 0247_ $$2DOI$$a10.6083/70795847m
000009974 037__ $$aETD
000009974 245__ $$aEngineering complex microenvironments by tailoring biophysical regulation for tissue engineering applications
000009974 260__ $$bOregon Health and Science University
000009974 269__ $$a2022
000009974 336__ $$aDissertation
000009974 502__ $$bPh.D.
000009974 520__ $$aThe extracellular matrix (ECM) plays a governing role in regulating functional cell and tissue behavior through biochemical and biophysical signaling. Ongoing tissue engineering efforts are focused on understanding these key interactions between cells and their extracellular matrix and recapitulating them to influence cell behavior in therapeutic contexts. Recent advancements in biomaterial engineering and microfabrication strategies have allowed decoupled presentation of various aspects of the ECM such as the biochemical composition, stiffness and microscale geometry in order to establish their individual regulatory functions. However, investigation of cell response to the combinatorial signaling derived from these factors is confounded by the dynamic nature of the interplay between these biophysical factors, particularly under conditions of higher order complexity. These challenges have been addressed here through the development of a novel  bioprinting derived strategy for the fabrication of three-dimensional (3D)  tissue models in high throughput, while also allowing simultaneous and independent modulation of matrix stiffness and microscale geometry.
000009974 542__ $$fIn copyright - single owner
000009974 650__ $$aHydrogels$$032129
000009974 650__ $$aExtracellular Matrix$$018796
000009974 650__ $$aTissue Engineering$$033051
000009974 650__ $$aBioprinting$$040002
000009974 6531_ $$acellular mechanotransduction
000009974 6531_ $$a3 d printing
000009974 691__ $$aSchool of Medicine$$041369
000009974 692__ $$aDepartment of Biomedical Engineering$$041397
000009974 7001_ $$aAthirasala, Avathamsa
000009974 8564_ $$91e393189-cfa4-4f72-bd93-aa0a839ad9a3$$s48057329$$uhttps://digitalcollections.ohsu.edu/record/9974/files/Athirasala.Avathamsa.2022.pdf
000009974 905__ $$a/rest/prod/70/79/58/47/70795847m
000009974 909CO $$ooai:digitalcollections.ohsu.edu:9974$$pstudent-work
000009974 980__ $$aTheses and Dissertations