000009981 001__ 9981 000009981 005__ 20240124114332.0 000009981 0247_ $$2DOI$$a10.6083/zs25x924j 000009981 037__ $$aETD 000009981 245__ $$aSynthesis and characterization of metal nanoparticles for spectrally-resolved single-particle localized surface plasmon resonance (LSPR) sensors 000009981 260__ $$bOregon Health and Science University 000009981 269__ $$a2023 000009981 336__ $$aDissertation 000009981 502__ $$bPh.D. 000009981 520__ $$aThis thesis work focuses on technical developments in the field of plasmonic nanomaterials and its related areas of synthesis and optical characterization. Metal nanoparticles are widely used materials for molecular sensors. While fluorescence-based omics analysis remains the mainstay for biomarker detection, development of label-free approaches are important in pushing the boundaries of diagnostic sensing. Plasmonic nanoparticles revolve around a phenomenon called localized surface plasmon resonance (LSPR). LSPR refers to the oscillation of conduction electrons confined in the metal structure where upon optical excitation, local field enhancements and enhanced light scattering and absorption will occur. 000009981 542__ $$fIn copyright - single owner 000009981 650__ $$aSurface Plasmon Resonance$$032345 000009981 650__ $$aOligonucleotides$$023188 000009981 650__ $$aNanoparticles$$037592 000009981 650__ $$aNanostructures$$036192 000009981 6531_ $$araman spectrum analysis 000009981 6531_ $$amolecular dynamics 000009981 691__ $$aSchool of Medicine$$041369 000009981 692__ $$aDepartment of Biomedical Engineering$$041397 000009981 7001_ $$aPalani, Stephen 000009981 8564_ $$98ce97213-2cba-4ef5-80cd-5f0a47bc423c$$s25956542$$uhttps://digitalcollections.ohsu.edu/record/9981/files/Palani.Stephen.2023.pdf 000009981 905__ $$a/rest/prod/zs/25/x9/24/zs25x924j 000009981 909CO $$ooai:digitalcollections.ohsu.edu:9981$$pstudent-work 000009981 980__ $$aTheses and Dissertations