000000999 001__ 999
000000999 005__ 20250501084958.0
000000999 0247_ $$2DOI$$a10.6083/M400004M
000000999 037__ $$aETD
000000999 245__ $$aIdentification and functional characterization of A-kinase anchoring proteins
000000999 260__ $$bOregon Health and Science University
000000999 269__ $$a2002-06-01
000000999 336__ $$aDissertation
000000999 502__ $$bPh.D.
000000999 520__ $$aCompartmentalization of signal transduction enzymes is an important mechanism for imparting cellular signaling specificity. This occurs through the interaction of enzymes with scaffolding or anchoring proteins. To date, one of the best-studied examples of kinase anchoring is the targeting of PKA to cellular locations through its association with A-kinase anchoring proteins (AKAPs). AKAPs mediate a high-affinity interaction with the type II regulatory subunit (RII) of PKA to localize the kinase to pools of cAMP and within proximity of preferred substrates. Furthermore, AKAPs can organize entire signaling complexes made up of kinases, phosphates, and regulatory proteins.
000000999 542__ $$fIn copyright - single owner
000000999 650__ $$aSignal Transduction$$028380
000000999 650__ $$aA Kinase Anchor Proteins$$038018
000000999 691__ $$aSchool of Medicine$$041369
000000999 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000999 7001_ $$aAlto, Neal$$uOregon Health and Science University$$041354
000000999 8564_ $$9a6b81f7a-f2d1-4618-be68-28ce242b7335$$s9666378$$uhttps://digitalcollections.ohsu.edu/record/999/files/1014_etd.pdf$$ePublic$$2c1275d802a2aef0b8337423f51f6cee1$$31
000000999 905__ $$a/rest/prod/2r/36/tx/57/2r36tx57k
000000999 909CO $$ooai:digitalcollections.ohsu.edu:999$$pstudent-work
000000999 980__ $$aTheses and Dissertations