Novel anti-CB1 monoclonal antibodies, including an N-terminal binding antibody, were characterized and validated. These antibodies were then used to investigate the role [...]

G protein-coupled receptors (GPCRs) play an essential role in signal transduction by transmitting extracellular stimuli into intracellular responses through activation of [...]

Structural biology is ultimately the study of particular domains and residues, but this knowledge most interesting and useful in the con-text of physiological processes. [...]

This dissertation explores the capacity of direct chemical modification of existing aptamer structures for the discovery of novel functional applications using a closely [...]

PARPs are a family of 17 proteins that regulate a diverse range of cellular processes through the transfer of ADP-ribose from NAD+ to amino acids on protein targets, a pr [...]

The Blackburn Lab studies biological copper chemistry using biochemical, biophysical, and advanced spectroscopic techniques. Our research aims are two-pronged, which is r [...]

Insulin is a hormone secreted by pancreatic B-cells in response to glucose stimulation. Proper insulin secretion keeps blood glucose in a physiological range by promoting [...]

Germin, a protein found in germinating wheat, has been identified as an oxalate oxidase (oxalate: oxygen oxidoreductase, EC 1.2.3.4) catalyzing the conversion of oxalate [...]

The epithelial sodium channel (ENaC) is expressed at the apical side of epithelial cells and is a key regulator of salt and water balance. By serving as the rate-limiting [...]

Bacillus subtilis Spx is a global transcriptional regulator that is conserved among gram-positive bacteria, in which Spx is required for preventing oxidatively induced [...]